SrasV1, Main, Exploration, bibRecord, 002394

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

Identifieur interne : 002394 ( Main/Exploration ); précédent : 002393; suivant : 002395

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

Auteurs : Jean-Paul Armache [Allemagne] ; Alexander Jarasch [Allemagne] ; Andreas M. Anger [Allemagne] ; Elizabeth Villa [Allemagne] ; Thomas Becker [Allemagne] ; Shashi Bhushan [Allemagne] ; Fabrice Jossinet [France] ; Michael Habeck [France] ; Gülcin Dindar [Allemagne] ; Sibylle Franckenberg [Allemagne] ; Viter Marquez [Allemagne] ; Thorsten Mielke [Allemagne] ; Michael Thomm [Allemagne] ; Otto Berninghausen [Allemagne] ; Birgitta Beatrix [Allemagne] ; Johannes Söding [Allemagne] ; Eric Westhof [France] ; Daniel N. Wilson [Allemagne] ; Roland Beckmann [Allemagne]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2010-10-27.

RBID : Hal:hal-00530586

Abstract

Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

Url:

https://hal.archives-ouvertes.fr/hal-00530586

DOI: 10.1073/pnas.1009999107

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000041
to stream Hal, to step Curation: 000041
to stream Hal, to step Checkpoint: 000133
to stream Main, to step Merge: 002425
to stream Main, to step Curation: 002394

Le document en format XML

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<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
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</author>
<author><name sortKey="Wilson, Daniel N" sort="Wilson, Daniel N" uniqKey="Wilson D" first="Daniel N" last="Wilson">Daniel N. Wilson</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-460216" status="VALID">          <orgName>Max Von Pettenkofer Institute</orgName>
          <orgName type="acronym">MVP</orgName>
          <desc>            <address>              <addrLine>Pettenkoferstraße 9a, 80336 Munich, Germany</addrLine>
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          <orgName type="acronym">LMU</orgName>
          <desc>            <address>              <addrLine>Geschwister-Scholl-Platz 1, 80539 München</addrLine>
              <country key="DE"></country>
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            <ref type="url">http://www.uni-muenchen.de</ref>
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        </org>
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</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Beckmann, Roland" sort="Beckmann, Roland" uniqKey="Beckmann R" first="Roland" last="Beckmann">Roland Beckmann</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-460216" status="VALID">          <orgName>Max Von Pettenkofer Institute</orgName>
          <orgName type="acronym">MVP</orgName>
          <desc>            <address>              <addrLine>Pettenkoferstraße 9a, 80336 Munich, Germany</addrLine>
              <country key="DE"></country>
            </address>
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          <orgName type="acronym">LMU</orgName>
          <desc>            <address>              <addrLine>Geschwister-Scholl-Platz 1, 80539 München</addrLine>
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<country>Allemagne</country>
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<idno type="DOI">10.1073/pnas.1009999107</idno>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America </title>
<idno type="ISSN">0027-8424</idno>
<imprint><date type="datePub">2010-10-27</date>
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<front><div type="abstract" xml:lang="en">              <p>Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Grand Est</li>
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<settlement><li>Strasbourg</li>
</settlement>
<orgName><li>Université de Strasbourg</li>
</orgName>
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<tree><country name="Allemagne"><noRegion><name sortKey="Armache, Jean Paul" sort="Armache, Jean Paul" uniqKey="Armache J" first="Jean-Paul" last="Armache">Jean-Paul Armache</name>
</noRegion>
<name sortKey="Anger, Andreas M" sort="Anger, Andreas M" uniqKey="Anger A" first="Andreas M" last="Anger">Andreas M. Anger</name>
<name sortKey="Beatrix, Birgitta" sort="Beatrix, Birgitta" uniqKey="Beatrix B" first="Birgitta" last="Beatrix">Birgitta Beatrix</name>
<name sortKey="Becker, Thomas" sort="Becker, Thomas" uniqKey="Becker T" first="Thomas" last="Becker">Thomas Becker</name>
<name sortKey="Beckmann, Roland" sort="Beckmann, Roland" uniqKey="Beckmann R" first="Roland" last="Beckmann">Roland Beckmann</name>
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<name sortKey="Bhushan, Shashi" sort="Bhushan, Shashi" uniqKey="Bhushan S" first="Shashi" last="Bhushan">Shashi Bhushan</name>
<name sortKey="Dindar, Gulcin" sort="Dindar, Gulcin" uniqKey="Dindar G" first="Gülcin" last="Dindar">Gülcin Dindar</name>
<name sortKey="Franckenberg, Sibylle" sort="Franckenberg, Sibylle" uniqKey="Franckenberg S" first="Sibylle" last="Franckenberg">Sibylle Franckenberg</name>
<name sortKey="Jarasch, Alexander" sort="Jarasch, Alexander" uniqKey="Jarasch A" first="Alexander" last="Jarasch">Alexander Jarasch</name>
<name sortKey="Marquez, Viter" sort="Marquez, Viter" uniqKey="Marquez V" first="Viter" last="Marquez">Viter Marquez</name>
<name sortKey="Mielke, Thorsten" sort="Mielke, Thorsten" uniqKey="Mielke T" first="Thorsten" last="Mielke">Thorsten Mielke</name>
<name sortKey="Soding, Johannes" sort="Soding, Johannes" uniqKey="Soding J" first="Johannes" last="Söding">Johannes Söding</name>
<name sortKey="Thomm, Michael" sort="Thomm, Michael" uniqKey="Thomm M" first="Michael" last="Thomm">Michael Thomm</name>
<name sortKey="Villa, Elizabeth" sort="Villa, Elizabeth" uniqKey="Villa E" first="Elizabeth" last="Villa">Elizabeth Villa</name>
<name sortKey="Wilson, Daniel N" sort="Wilson, Daniel N" uniqKey="Wilson D" first="Daniel N" last="Wilson">Daniel N. Wilson</name>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Jossinet, Fabrice" sort="Jossinet, Fabrice" uniqKey="Jossinet F" first="Fabrice" last="Jossinet">Fabrice Jossinet</name>
</region>
<name sortKey="Habeck, Michael" sort="Habeck, Michael" uniqKey="Habeck M" first="Michael" last="Habeck">Michael Habeck</name>
<name sortKey="Westhof, Eric" sort="Westhof, Eric" uniqKey="Westhof E" first="Eric" last="Westhof">Eric Westhof</name>
</country>
</tree>
</affiliations>
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Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

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